Trial Acronym | Trial objective | Principal investigator | Participating countries |
ESOPEC | Perioperative Chemotherapy Compared To Neoadjuvant Chemoradiation in Patients With Adenocarcinoma of the Esophagus | J Hoeppner (GR) | GR |
NeoAEGIS | To compare neoadjuvant chemotherapy (MAGIC regimen) to neoadjuvant chemoradiotherapy (CROSS regimen) in junctional adenocarcinoma | JV Reynolds (IRL) | IRL, UK, FR, DEN |
ESOSTRATE – PRODIGE 32 | To compare systematic surgery versus surveillance in complete morphological responders to chemoradiotherapy in oesophageal cancer | L Bedenne – C Mariette (FR) | FR |
ROMIO | To compare hybrid vs totally mini-invasive vs open oesophagectomy in oesophageal cancer | J Blazeby (UK) | UK |
Pre-SANO | Correlation between clinical Complete Response and pathological Complete Response after neoadjuvant chemoradiotherapy | JJB Van Lanschot (NL) | NL |
PROTECT | To compare 2 neoadjuvant chemoradiotherapy regimen in oesophageal cancer: Carboplatin-Paclitaxel +radiotherapy (CROSS regimen) vs. Folfox + radiotherapy | A Adenis – C Mariette (FR) | FR |
FREGAT | Multicenter, Nationwide Prospective data collection of clinical, tumoural, biological, quality of life and human and social sciences data for oesphageal and gastric cancer patients | C Mariette (FR) | FR |
ROBOT | Robot vs open transthoracic oesophagectomy for oesophageal cancer | R. van Hillegersberg (NL) | NL |
CONCORDE – PRODIGE 26 | Radiotherapy dose escalation in definitive chemoradiotherapy for oesophageal cancer 50.4 Gy vs. 64 Gy | G Crehange (FR) | FR |
ART deco | Radiotherapy dose escalation in definitive chemoradiotherapy for oesophageal cancer 50.4 Gy vs. 61.6 Gy | M.C.C.M. Hulshof (NL) | NL |
NEORES II | Randomized clinical trial comparing the timing of resective surgery after neoadjuvant chemoradiotherapy in cancer of the esophagus or gastric cardia |
The European Society for Esophageal Disease 2022